Thursday, October 2, 2025

Christian McCaffrey’s Season Potentially Over After Knee Injury

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San Francisco 49ers Running Back Christian McCaffrey Suffers Potentially Season-Ending Knee Injury

Injury Details

San Francisco running back Christian McCaffrey suffered a knee injury that coach Kyle Shanahan described as "potentially" season-ending in the 49ers’ 35-10 loss to the Buffalo Bills on Sunday night. Shanahan said McCaffrey is believed to have injured his posterior cruciate ligament (PCL), which connects the thigh bone to the shin. He stated that he has no timetable for McCaffrey’s return, but acknowledged that the All-Pro’s season could be over.

Impact on the Team

The injury is the latest setback in a frustrating season for McCaffrey, who missed the Niners’ first eight games with Achilles tendinitis and has not been his usual explosive self since returning. The 49ers have battled injuries all season, were missing five starters against Buffalo, and dropped their third straight. San Francisco (5-7) sits alone in last in the NFC West standings, two wins behind division-leading Seattle, and in jeopardy of missing the playoffs a year after losing to Kansas City in the Super Bowl.

Quotable Quotes

"He’s one of the best running backs in the league," quarterback Brock Purdy said. "When you lose him like that, I think it takes away just sort of how we do some things in the offense."

"It looked like he just got shoe-stringed there, he was about to break a house call," Shanahan said. "It was frustrating. He had a great week of practice. I could feel his urgency and stuff. Thought he came out great, looking real good."

Game Recap

The 49ers had success rushing for 153 yards in snowy conditions. J.P. Mason had 73 yards on 13 carries, and Issac Guerendo ran for a 15-yard touchdown in the third quarter. However, very little went right for the 49ers in a game that was played in wintry conditions, with snow falling throughout the night. Jake Moody missed two of three field-goal attempts, and San Francisco lost three fumbles, including fullback Kyle Juszczyk getting the ball punched out of his arms at the Buffalo 1 to end San Francisco’s first drive of the second half.

Conclusion

The injury to McCaffrey is a significant blow to the 49ers’ chances of making a playoff run. The team will need to regroup and find a way to replace his production if they hope to turn their season around.

FAQs

Q: What is the nature of Christian McCaffrey’s knee injury?
A: McCaffrey is believed to have injured his posterior cruciate ligament (PCL).

Q: Is McCaffrey’s season potentially over?
A: Yes, coach Kyle Shanahan acknowledged that McCaffrey’s season could be over due to the injury.

Q: How will the 49ers replace McCaffrey’s production?
A: The team will need to regroup and find a way to replace McCaffrey’s production through a combination of running backs, including J.P. Mason and Issac Guerendo.

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