Introduction to Lipoprotein(a)
Researchers have discovered an experimental medication that significantly reduces a cholesterol-like particle that can increase the risk of heart attacks and strokes. Many Americans are unaware that elevated levels of this particle — known as lipoprotein(a) or Lp(a) — are circulating in their blood. Elevated Lp(a) cannot be modified with lifestyle changes, and has been called “one of the last untreatable frontiers of cardiovascular risk” by Cleveland Clinic, who led the study.
What to know about Lp(a)
Lipoprotein(a) levels are elevated in approximately 20-25% of people worldwide, according to the American Heart Association. This equates to approximately 64 million people in the U.S. and 1.4 billion people globally. Lp(a) shares similarities with another lipoprotein that doctors target to reduce the risk of heart disease, known as low-density lipoprotein (LDL) – often referred to as “bad cholesterol.” But lipoprotein(a) is more prone to plaque buildup and clots in the arteries than LDL, according to lead author Steven Nissen, M.D., chief academic officer of the Heart, Vascular & Thoracic Institute at Cleveland Clinic.
Lipoprotein(a) and Genetics
“Lipoprotein(a) is an independent risk factor for heart disease that is largely determined by genetics — that is, it is inherited,” added Dr. Deepak L. Bhatt, director of Mount Sinai Fuster Heart Hospital and a professor of cardiovascular medicine at Icahn School of Medicine at Mount Sinai in New York, told Fox News Digital. (He was not part of the study.) Lp(a) is primarily determined by differences in one gene, while LDL cholesterol levels are influenced by multiple genes. “That’s a very big difference, and LDL has a much larger environmental component,” Nissen noted.
Current Treatments for Lp(a)
Diet, exercise and weight loss can help decrease LDL levels, but they do not have an impact on Lp(a) levels, experts say. And unlike LDL, which can be reduced with medications like statins, there are currently no approved drug treatments that lower Lp(a). “There is no approved pharmacotherapy for lipoprotein(a) by regulatory authorities in any country in the world,” Nissen confirmed.
Study Design
The researchers performed a clinical trial of 320 individuals from Argentina, China, Denmark, Germany, Japan, Mexico, the Netherlands, Romania, Spain and the U.S. from Nov. 11, 2022, to April 17, 2023. The participants were randomly assigned to receive either a placebo or one or two subcutaneous injections of lepodisiran. The normal level of Lp(a) is less than 75 nanomoles per liter and the average level for people in the trial was about 250 nanomoles per liter, Nissen told Fox News Digital. “They were very high — more than three times the upper limit of normal,” he added.
Results of the Study
After one injection of the highest dose, participants showed a nearly 100% reduction in levels of lipoprotein(a) at six months. Those who received a second dose at six months maintained an almost 100% reduction at the one-year mark. In other words, the therapy removed virtually all lipoprotein(a) from the blood, according to Nissen. Cardiologists say these findings may ultimately help treat millions of Americans who have elevated levels of Lp(a). “The results are very impressive,” Bhatt said.
Potential Limitations
The researchers noted that there were no major safety concerns, but 12% of participants reported mild reactions at the injection site. The study had only a few Black participants — a population that needs more research, as they are more likely to have elevated lipoprotein(a) concentrations than White persons, according to previous studies. (To address this concern, the researchers are enrolling many more Black patients in their larger phase 3 clinical trial.) Another limitation was that only two doses of lepodisiran were administered in the trial, so the effect of more doses is not known. The study also did not show that reducing Lp(a) levels also reduces the risk of heart attacks and strokes, outside experts noted.
Need for Further Research
“A phase 3 trial testing the clinical impact of this drug is needed to see if the large reduction of Lp(a) translates into lower rates of heart attack,” Bhatt said. Nissen confirmed that the phase 3 trial to address this question is already underway. The European Society of Cardiology and the National Lipid Association in the U.S. both recommend that all adults check their Lp(a) levels. “I have been checking Lp(a) levels in all patients for many years,” Bhatt said. But unlike traditional cholesterol, which doctors typically monitor over time, Nissen pointed out that lipoprotein(a) only needs to be checked once in a lifetime. “Whatever your level is when you’re 24 years old is the level when you’re 64 years old – it doesn’t change, because it’s genetic,” he said. “So you only need to get it once, and if you get it early in life, then you know you’re at risk, and you can live your life accordingly.”
Conclusion
In conclusion, the study shows that the experimental drug lepodisiran can significantly reduce lipoprotein(a) levels, which is a major risk factor for heart disease. While the results are promising, further research is needed to confirm the safety and efficacy of the drug and to determine its potential to reduce the risk of heart attacks and strokes.
FAQs
- Q: What is lipoprotein(a) and how does it affect the body?
A: Lipoprotein(a) is a type of cholesterol-like particle that can increase the risk of heart attacks and strokes. It is more prone to plaque buildup and clots in the arteries than LDL cholesterol. - Q: Can lipoprotein(a) levels be reduced with lifestyle changes?
A: No, lipoprotein(a) levels cannot be modified with lifestyle changes such as diet, exercise, and weight loss. - Q: Is there a treatment available for elevated lipoprotein(a) levels?
A: Currently, there are no approved drug treatments that lower lipoprotein(a) levels, but the experimental drug lepodisiran has shown promising results in reducing Lp(a) levels. - Q: How often should lipoprotein(a) levels be checked?
A: Lipoprotein(a) levels only need to be checked once in a lifetime, as they do not change over time due to genetic factors.
