Cutting Edge Hair Loss Treatment is Repurposed Drug from 1990s

Introduction to Hair Loss Treatment

The latest trend in treating hair loss may sound familiar — essentially, it’s a repurposed drug first popularized in the 1990s. Back then, TV viewers were inundated with ads for Rogaine, a sticky topical solution that could help treat thinning hair when applied to the scalp. Now dermatologists are increasingly prescribing the drug, known generically as minoxidil, in low-dose pills to help men and women maintain or regrow hair.

A Retro Approach to Hair Loss

Minoxidil was originally developed as a pill to treat high blood pressure in the 1970s. Researchers noticed that some patients taking it experienced increased hair growth as a side effect. Rogaine was approved by the Food and Drug Administration in 1988, the first drug to win the agency’s endorsement for male pattern baldness. Studies showed that men on the medication, which was applied directly to the scalp, had a slower rate of hair loss and, in some cases, regrew hair. Starting in 1991, a lower dose was approved for women and the brand was aggressively marketed as an over-the-counter medication on TV and in print. The drug’s ability to slow hair loss is likely related to its effect on blood circulation, according to experts.

“By increasing blood flow to the scalp it signals hairs to stay in their grow phase for longer,” said Dr. Adam Friedman, chair of dermatology at George Washington University. “We’re trying to keep those hairs in that growth phase as long as possible.” A recent consensus paper by more than 40 U.S. and international dermatologists concluded that minoxidil pills are effective and often more convenient and affordable than the liquid formulation.

Patients Prefer the Pill

There’s little research comparing the two forms of minoxidil, but many dermatologists believe the drug works better as a pill. At a chemical level, minoxidil is absorbed more directly when digested in the gut than when applied to the hairline. It’s also more convenient, with patients taking the drug by mouth once a day, instead of applying the liquid once or twice daily using a dropper. “As you can imagine, that can be rather onerous,” said Dr. Susan Taylor of the University of Pennsylvania. “Although people often enthusiastically begin therapy— and even see results — after a while there are many who drop off.” The doses prescribed for oral use are also very low. Dermatologists often direct men to take one half of the lowest-dose pill; women may only need a quarter of a pill.

Why Aren’t Minoxidil Pills FDA-Approved for Hair Loss?

In short, because there’s very little money to be made. Minoxidil’s patent has expired and it is now available as a low-cost generic medication. That means drugmakers have little financial incentive to spend millions on the new studies that would be needed to win FDA approval for hair loss. “For a drug like oral minoxidil — which is as old as dirt at this point — there are no reasons to do that,” said Friedman. Like other dermatologists, Friedman gives hair-loss patients a prescription for the pills intended to treat blood pressure, a practice known as off-label prescribing. The upside for patients is that minoxidil is extremely affordable, with some pharmacies offering a month’s supply for less than $5. “Not a single patient has complained to me about the cost of this medication, which is extremely rare,” said Dr. Luiz Garza of Johns Hopkins University.

Telehealth Firms Open Up Access

The vast majority of doctors prescribing minoxidil for hair loss are dermatologists, who often turn to older drugs off-label for various hair and skin conditions. A survey of U.S. dermatologists published last year found 80% reported prescribing oral minoxidil. But with only about 12,000 dermatologists in the U.S., some patients may have trouble finding a provider. Telehealth providers like Hims and Ro say they are helping fill the gap. The companies’ business model offers patients quick access to the medications they are seeking, often after simply filling out a questionnaire about their medical history, medications and treatment goals. The information is reviewed by a health provider who can quickly approve a prescription, assuming there are no red flags.

Conclusion

In conclusion, the repurposed drug minoxidil, originally developed to treat high blood pressure, has been found to be effective in treating hair loss when taken in low-dose pills. While it is not FDA-approved for hair loss due to lack of financial incentive for drugmakers, dermatologists are increasingly prescribing it off-label. The drug is affordable and convenient, and telehealth firms are making it more accessible to patients. However, many dermatologists recommend in-person appointments for a thorough evaluation and discussion of the drug’s side effects.

FAQs

• What is minoxidil and how does it work? Minoxidil is a drug that was originally developed to treat high blood pressure, but it has been found to be effective in treating hair loss. It works by increasing blood flow to the scalp, signaling hairs to stay in their grow phase for longer.
• Is minoxidil FDA-approved for hair loss? No, minoxidil is not FDA-approved for hair loss, but it is often prescribed off-label by dermatologists.
• What are the side effects of minoxidil? The side effects of minoxidil can include dizziness, rapid heartbeat, and swollen legs. It is not recommended for people with a history of heart issues or who are pregnant or breastfeeding.
• How much does minoxidil cost? Minoxidil is extremely affordable, with some pharmacies offering a month’s supply for less than $5.
• Can I get minoxidil through telehealth firms? Yes, telehealth firms like Hims and Ro offer minoxidil prescriptions after a quick online questionnaire and review by a health provider.